Title : Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.

Pub. Date : 2013 Oct

PMID : 23846873






1 Functional Relationships(s)
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1 We reported previously that MC treatment triggers a pronounced downregulation, particularly at the protein level, of mouse hepatic Cyp3a11, a counterpart of the key human drug-metabolizing enzyme CYP3A4. Methylcholanthrene cytochrome P450 family 3 subfamily A member 4 Homo sapiens