Pub. Date : 2013 Oct 24
PMID : 23845848
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolism by CYP3A4 is only known for dihydrodiol metabolites of PAH but not for their parent compounds. | trans-1,2-dihydro-1,2-naphthalenediol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In the present study, a CYP3A4 reporter gene assay, requiring the overexpression of PXR, was used to investigate whether the PAH parent compounds BaP, benzo[c]phenanthrene (BcP) and dibenzo[a,l]pyrene (DBalP) as well as their corresponding phase I metabolites, the respective dihydrodiols and diol epoxides, can induce CYP3A4 promoter activity. | trans-1,2-dihydro-1,2-naphthalenediol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | BaP, BcP and their dihydrodiols were found to significantly activate the CYP3A4 promoter. | trans-1,2-dihydro-1,2-naphthalenediol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |