Title : Clinical effects of A4889G and T6235C polymorphisms in cytochrome P-450 CYP1A1 for breast cancer patients treated with tamoxifen: implications for tumor aggressiveness and patient survival.

Pub. Date : 2013 Sep

PMID : 23842721






1 Functional Relationships(s)
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1 Two polymorphisms of the CYP1A1 gene-A4889G and T6235C-are known to affect activation of estrone and estradiol and to deregulate concentration of highly active tamoxifen metabolites. Estradiol cytochrome P450 family 1 subfamily A member 1 Homo sapiens