Title : Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.

Pub. Date : 2013

PMID : 23840602






2 Functional Relationships(s)
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1 Increasing concentrations of cobalt ions significantly up-regulated HIF-1alpha with a maximal response at 0.3 mM. Cobalt hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Cobalt-alloy particles (1 um-diameter, 10 particles/cell) induced significantly elevated HIF-1alpha, VEGF, TNF-alpha and ROS expression in human primary macrophages whereas Titanium-alloy particles did not. Cobalt hypoxia inducible factor 1 subunit alpha Homo sapiens