Pub. Date : 2013 Oct
PMID : 23836294
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 2 | Ghrelin and nicotine activates the mesolimbicocortical dopaminergic pathways via growth hormone secretagogue receptors (GHS-R1A) and nicotinic acetylcholine receptors (nAchR), respectively, resulting in the release of dopamine in the nucleus accumbens, the amygdala and the prefrontal cortex. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 3 | In the present study an in vitro superfusion of rat amygdalar slices was performed in order to investigate the direct action of ghrelin and nicotine on the amygdalar dopamine release. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 4 | Ghrelin increased significantly the dopamine release from the rat amygdala following electrical stimulation. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 5 | Co-administration of ghrelin and nicotine induced a similar increase of amygdalar dopamine release. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |
| 6 | The present results demonstrate that both ghrelin and nicotine stimulates directly the dopamine release in the amygdala, an important dopaminergic target area of the mesolimbicocortical pathway. | Dopamine | ghrelin and obestatin prepropeptide | Rattus norvegicus |