Title : Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells.

Pub. Date : 2013 Aug

PMID : 23834842






2 Functional Relationships(s)
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1 Indeed, using the calcineurin inhibitor Cyclosporine A to inhibit signaling downstream of PLCgamma, we found that Cyclosporine A attenuated antigen-specific Tconv proliferation but permitted IL-2-induced regulatory T cell expansion in vitro and in vivo. Cyclosporine interleukin 2 Mus musculus
2 Indeed, using the calcineurin inhibitor Cyclosporine A to inhibit signaling downstream of PLCgamma, we found that Cyclosporine A attenuated antigen-specific Tconv proliferation but permitted IL-2-induced regulatory T cell expansion in vitro and in vivo. Cyclosporine interleukin 2 Mus musculus