Title : APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.

Pub. Date : 2014 May 1

PMID : 23831342






4 Functional Relationships(s)
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1 RESULTS: General linear model analysis demonstrated that older APOE E4 carriers had significantly higher choline/creatine and myo-inositol/creatine ratios than APOE E3 homozygotes. Inositol apolipoprotein E Homo sapiens
2 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol apolipoprotein E Homo sapiens
3 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol apolipoprotein E Homo sapiens
4 CONCLUSIONS: In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers. Inositol apolipoprotein E Homo sapiens