Pub. Date : 2013
PMID : 23825542
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitate-induced SeP expression was inhibited by both salsalate and salicylate, which was mediated by AMPK activation, and was blocked by AMPK siRNA or an inhibitor of AMPK. | salicylsalicylic acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | Chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift (EMSA) assay showed that salsalate suppressed SeP expression by AMPK-mediated phosphorylation of FOXO1alpha. | salicylsalicylic acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway. | salicylsalicylic acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |