Title : Activation of RAW264.7 mouse macrophage cells in vitro through treatment with recombinant ricin toxin-binding subunit B: involvement of protein tyrosine, NF-κB and JAK-STAT kinase signaling pathways.

Pub. Date : 2013 Sep

PMID : 23820591






1 Functional Relationships(s)
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1 The recombinant RTB-induced production of NO, TNF-alpha and IL-6 was inhibited in the macrophages treated with the pharmacological inhibitors genistein, LY294002, staurosporine, AG490, SB203580 and BAY 11-7082, indicating the possible involvement of protein tyrosine kinases, PI3K, PKC, JAK2, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB in the above processes. Genistein interleukin 6 Mus musculus