Pub. Date : 1990 Aug 15
PMID : 2380554
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To understand the mode of action of these compounds a large panel of SP were examined for their ability to inhibit HIV infection, block anti-CD4 mAb binding and, when immobilized, bind soluble CD4 and virion gp120. | sp | CD4 molecule | Homo sapiens |
| 2 | To understand the mode of action of these compounds a large panel of SP were examined for their ability to inhibit HIV infection, block anti-CD4 mAb binding and, when immobilized, bind soluble CD4 and virion gp120. | sp | CD4 molecule | Homo sapiens |
| 3 | Based on anti-CD4 mAb binding-inhibition studies a SP binding site was identified on the CD4 molecule. | sp | CD4 molecule | Homo sapiens |
| 4 | Based on anti-CD4 mAb binding-inhibition studies a SP binding site was identified on the CD4 molecule. | sp | CD4 molecule | Homo sapiens |
| 5 | In fact, DXS-500 kDa exhibited an hierarchy of inhibition of anti-CD4 mAb which suggests that SP bind to a conformational site incorporating the first two Ig-like domains of CD4. | sp | CD4 molecule | Homo sapiens |
| 6 | In fact, DXS-500 kDa exhibited an hierarchy of inhibition of anti-CD4 mAb which suggests that SP bind to a conformational site incorporating the first two Ig-like domains of CD4. | sp | CD4 molecule | Homo sapiens |
| 7 | This SP binding site is clearly distinct but closely associated with the gp120 binding region of CD4. | sp | CD4 molecule | Homo sapiens |
| 8 | In contrast, many of the SP tested showed some affinity for CD4 based on anti-CD4 mAb blocking studies and binding of soluble CD4 to immobilized SP. | sp | CD4 molecule | Homo sapiens |
| 9 | In contrast, many of the SP tested showed some affinity for CD4 based on anti-CD4 mAb blocking studies and binding of soluble CD4 to immobilized SP. | sp | CD4 molecule | Homo sapiens |
| 10 | In contrast, many of the SP tested showed some affinity for CD4 based on anti-CD4 mAb blocking studies and binding of soluble CD4 to immobilized SP. | sp | CD4 molecule | Homo sapiens |
| 11 | In contrast, many of the SP tested showed some affinity for CD4 based on anti-CD4 mAb blocking studies and binding of soluble CD4 to immobilized SP. | sp | CD4 molecule | Homo sapiens |
| 12 | However, with SP such as heparin, fucoidan, the carrageenans, and polyanethole sulfonate, although CD4 blocking may contribute to anti-HIV activity, some other anti-viral mechanism is also operating. | sp | CD4 molecule | Homo sapiens |