Title : Peroxisome proliferator-activated receptor γ, coactivator 1α deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation.

Pub. Date : 2013 Aug

PMID : 23788763






1 Functional Relationships(s)
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1 By using the mitochondrial-specific superoxide dye MitoSox and complex I inhibitor rotenone, we identified the mitochondrial respiratory chain as the major PGC-1alpha-dependent reactive oxygen species source in vivo, accompanied by increased vascular inflammation and cell senescence. Superoxides peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus