Title : E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors.

Pub. Date : 2013 Aug

PMID : 23780739






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The distal amino group of the hydrazide moiety addresses the acidic Asp 1 residue at the entrance of the S2 pocket by hydrogen bonding while also occupying the flat hydrophobic S1"-S2" area with its leucine-isoamylamide moiety. Hydrogen beta-secretase 2 Homo sapiens