Title : Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway.

Pub. Date : 2013 Oct

PMID : 23777859






2 Functional Relationships(s)
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1 The PTN/RPTPbeta/zeta signaling pathway thus regulates the catalytic activity of ALK and tyrosine phosphorylation levels of ALK downstream target proteins. Tyrosine ALK receptor tyrosine kinase Homo sapiens
2 Furthermore, since ALK is only one of the key ALK phosphoproteins targeted by the PTN/RPTPbeta/zeta signaling pathway, the PTN/RPTPbeta/zeta signaling pathway has the potential to coordinately regulate tyrosine phosphorylation of other different key proteins in multiple cellular compartments. Tyrosine ALK receptor tyrosine kinase Homo sapiens