Pub. Date : 2013 Sep
PMID : 23772748
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin has been shown to attenuate diabetic nephropathy in rats by decreasing transforming growth factor-beta (TGF-beta) and type IV collagen expression, but its mode of action in glomerular mesangial cells is uncertain. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | Mesangial cells treated with icariin after TGF-beta1 exposure expressed less type IV collagen and fibronectin than those without icariin treatment, suggesting inhibition by icariin of TGF-beta1 downstream pathways. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | Mesangial cells treated with icariin after TGF-beta1 exposure expressed less type IV collagen and fibronectin than those without icariin treatment, suggesting inhibition by icariin of TGF-beta1 downstream pathways. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | On TGF-beta1 stimulation, icariin inhibited TGF-beta canonical Smad signalling and extracellular signal-regulated kinase (ERK)1/2 signalling by decreasing Smad2/3 and ERK1/2 phosphorylation in a dose-dependent manner. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | On TGF-beta1 stimulation, icariin inhibited TGF-beta canonical Smad signalling and extracellular signal-regulated kinase (ERK)1/2 signalling by decreasing Smad2/3 and ERK1/2 phosphorylation in a dose-dependent manner. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |
| 6 | The G protein-coupled oestrogen receptor 1 (GPER) antagonist, G-15, abolished the icariin-induced inhibition of type IV collagen, and fibronectin overproduction and TGF-beta signalling. | icariin | transforming growth factor, beta 1 | Rattus norvegicus |