Title : Total glucosides of peony attenuates 2,4,6-trinitrobenzene sulfonic acid/ethanol-induced colitis in rats through adjustment of TH1/TH2 cytokines polarization.

Pub. Date : 2014 Jan

PMID : 23771723






3 Functional Relationships(s)
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1 Moreover, administration of TGP (50 or 100 mg/kg/day) decreased the up-regulated levels of serum TNF-alpha and IL-1beta, and expression of TNF-alpha and IL-1beta mRNA and protein in colonic tissues, and increased the serum IL-10 and colonic IL-10 mRNA and protein level. tgp tumor necrosis factor Rattus norvegicus
2 Moreover, administration of TGP (50 or 100 mg/kg/day) decreased the up-regulated levels of serum TNF-alpha and IL-1beta, and expression of TNF-alpha and IL-1beta mRNA and protein in colonic tissues, and increased the serum IL-10 and colonic IL-10 mRNA and protein level. tgp tumor necrosis factor Rattus norvegicus
3 TGP attenuates TNBS/ethanol-induced colitis in rats and its efficacy is similar to SASP, the potential mechanism might be related to the adjustment of Th1/Th2 cytokines polarization by decreasing pro-inflammatory cytokine TNF-alpha and IL-1beta, and increasing anti-inflammatory cytokine IL-10. tgp tumor necrosis factor Rattus norvegicus