Title : Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib.

Pub. Date : 2013 Oct 1

PMID : 23770382






1 Functional Relationships(s)
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1 Consistent with in vitro profile, oral dose of 40mg/kg nilotinib significantly decreased the cardiotoxicity of DOX in rat by enhancing P-gp activity in the heart. Doxorubicin ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus