Title : The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.

Pub. Date : 2013 Sep 15

PMID : 23769925






2 Functional Relationships(s)
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1 Finally, the peroxisome-proliferator activated receptor alpha (PPARalpha) and sterol regulatory element-binding protein-1 (SREBP-1) pathways known to have a central role in regulating free fatty acid metabolism were downregulated in the livers, but not in the adipose or muscle, of C57BL/6J Npc1+/- mice compared to C57BL/6J Npc1+/+ mice. Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus
2 Finally, the peroxisome-proliferator activated receptor alpha (PPARalpha) and sterol regulatory element-binding protein-1 (SREBP-1) pathways known to have a central role in regulating free fatty acid metabolism were downregulated in the livers, but not in the adipose or muscle, of C57BL/6J Npc1+/- mice compared to C57BL/6J Npc1+/+ mice. Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus