Title : Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour.

Pub. Date : 2013 Nov

PMID : 23768751






2 Functional Relationships(s)
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1 Recent post-mortem studies have shown that spermidine/spermine N1-acetyltransferase (SAT1), the key regulator of cellular polyamine content, is under-expressed in brains from suicide victims compared to controls. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
2 Our findings suggest that SAT1 transcription is influenced by lithium and that this effect is altered in BD patients who completed suicide, further supporting a role for polyamines in suicide. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens