Title : Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes.

Pub. Date : 2013 Sep 1

PMID : 23767959






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens
2 DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens
3 DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens
4 DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens
5 We also found that GW4064 and PA promote the phosphorylation of mTOR, Akt and FoxO1 (forkhead box O1), and that silencing DGKtheta expression significantly abrogated the ability of GW4046 to promote the phosphorylation of these PA-regulated targets. Phosphatidic Acids mechanistic target of rapamycin kinase Homo sapiens