Pub. Date : 2013 Sep
PMID : 23764356
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protective effects of puerarin on liver damage were evaluated by carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. | puerarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | In addition, puerarin at different doses significantly decreased (p<0.05) the level of hepatic thiobarbituric acid reactive substances compared to the CCl4-treated group. | puerarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Furthermore, the treatment of puerarin was also found to significantly increase the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glutathione content at least 40%, 12%, 25%, 52%, 17% and 44% in the liver of CCl4-treated rats, respectively. | puerarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | Liver histopathology also showed that puerarin reduced the incidence of liver lesions induced by CCl4. | puerarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | The results suggest that puerarin exhibits potent hepatoprotective effects on CCl4-induced liver damages in rats, and that the hepatoprotective effects of puerarin may be due to both the inhibition of lipid peroxidation and to increase of antioxidant enzymes activity. | puerarin | C-C motif chemokine ligand 4 | Rattus norvegicus |