Title : Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation.

Pub. Date : 2013 Jun 9

PMID : 23759023






1 Functional Relationships(s)
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1 Either dexmedetomidine or AG490 inhibited the phosphorylations of JAK2 and its downstream molecule STAT1 and STAT3, accompanied by down-regulation the expression of cleaved caspase 3, ICAM-1 and MCP-1 proteins, and significantly ameliorated renal I/R injury. Dexmedetomidine Janus kinase 2 Rattus norvegicus