Title : cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2.

Pub. Date : 2013 Aug 8

PMID : 23757730






2 Functional Relationships(s)
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1 Knockdown and specific rescue approaches reveal that a functional AnxA2-S100A10 complex is required for the forskolin-induced, cAMP-dependent release of VWF. Cyclic AMP von Willebrand factor Homo sapiens
2 Thus, complex formation of AnxA2 with S100A10 is a central regulatory mechanism in the acute release of VWF in response to cAMP-elevating agonists. Cyclic AMP von Willebrand factor Homo sapiens