Title : Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study.

Pub. Date : 2013 Aug

PMID : 23756919






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 There was a strong correlation between hepatic CES-2 expression and activation of irinotecan (r (2) = 0.96, p < 0.001). Irinotecan carboxylesterase 2 Homo sapiens
2 Hepatic CES-2 mediated activation of irinotecan clearly correlated with tumour replacement by fibrosis (r (2) = 0.54, p = 0.01). Irinotecan carboxylesterase 2 Homo sapiens