Title : Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure.

Pub. Date : 2013

PMID : 23755147






2 Functional Relationships(s)
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Protein Name
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1 All mutants bound ATP and ATP mimetic inhibitors with comparable IC50 values suggesting that the studied Pim-1 kinase mutants can be efficiently targeted with inhibitors developed for the wild type protein. Adenosine Triphosphate Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens
2 All mutants bound ATP and ATP mimetic inhibitors with comparable IC50 values suggesting that the studied Pim-1 kinase mutants can be efficiently targeted with inhibitors developed for the wild type protein. Adenosine Triphosphate Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens