Title : Differential and competitive regulation of human melanocortin 1 receptor signaling by β-arrestin isoforms.

Pub. Date : 2013 Aug 15

PMID : 23750009






1 Functional Relationships(s)
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1 Using a combination of co-immunoprecipitation, gel filtration chromatography, confocal microscopy, siRNA-mediated knockdown and functional assays, we demonstrated agonist-independent competitive interactions of ARRB1 and ARRB2 with MC1R, which might also be independent of phosphorylation of Ser/Thr residues in the C-terminus of the MC1R. Threonine arrestin beta 2 Homo sapiens