Title : Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.

Pub. Date : 2013 Aug 15

PMID : 23748423






3 Functional Relationships(s)
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1 Nicotine in the same plasma concentration range found in smokers increased the CD36(+)/CD14(+) cell population in human peripheral blood mononuclear cells, increased CD36 expression of human THP1 macrophages, and increased macrophage production of reactive oxygen species, PKCdelta phosphorylation, and peroxisome proliferator-activated receptor-gamma (PPARgamma) expression. Nicotine peroxisome proliferator activated receptor gamma Homo sapiens
2 Nicotine in the same plasma concentration range found in smokers increased the CD36(+)/CD14(+) cell population in human peripheral blood mononuclear cells, increased CD36 expression of human THP1 macrophages, and increased macrophage production of reactive oxygen species, PKCdelta phosphorylation, and peroxisome proliferator-activated receptor-gamma (PPARgamma) expression. Nicotine peroxisome proliferator activated receptor gamma Homo sapiens
3 Nicotine-induced CD36 expression was suppressed by antioxidants and by specific PKCdelta and PPARgamma inhibitors, implicating mechanistic roles for these intermediates. Nicotine peroxisome proliferator activated receptor gamma Homo sapiens