Pub. Date : 2012 Sep
PMID : 23741252
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by IFN-gamma was also significantly inhibited by EGCG. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 2 | Phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by IFN-gamma was also significantly inhibited by EGCG. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 3 | Reporter assays indicated that EGCG inhibited the transcriptional activities of IDO promoters, IFN-stimulated response element and IFN-gamma activation sequence, activated by STAT1 phosphorylation. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 4 | These findings suggest that EGCG may exert antitumor effects on CRC, at least in part, by inhibiting the expression and function of IDO through the suppression of STAT1 activation. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |