Title : Effect of endocannabinoids on IgE-mediated allergic response in RBL-2H3 cells.

Pub. Date : 2013 Sep

PMID : 23731947






2 Functional Relationships(s)
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1 Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines. na-5ht mitogen activated protein kinase 3 Rattus norvegicus
2 From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits. na-5ht mitogen activated protein kinase 3 Rattus norvegicus