Title : The relative roles of the glutathione redox cycle and catalase in the detoxification of H2O2 by cultured rabbit lens epithelial cells.

Pub. Date : 1990 Jun

PMID : 2373171






5 Functional Relationships(s)
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1 The relative roles of the glutathione redox cycle and catalase in the detoxification of H2O2 by cultured rabbit lens epithelial cells. Hydrogen Peroxide catalase Oryctolagus cuniculus
2 The relative roles of the glutathione redox cycle and catalase in the detoxification of H2O2 were investigated in cultured rabbit lens epithelial cells. Hydrogen Peroxide catalase Oryctolagus cuniculus
3 In contrast, cells with completely inhibited catalase but with an unimpaired glutathione redox cycle suffered few damaging effects from a 3-hr exposure to 0.025 mM H2O2. Hydrogen Peroxide catalase Oryctolagus cuniculus
4 When lens cells were pulsed with a single challenge of 0.5 mM H2O2, both the glutathione redox cycle and catalase were found to be essential for survival of the cells. Hydrogen Peroxide catalase Oryctolagus cuniculus
5 The cause of cell death following inhibition of catalase appeared to be related to an inability of the cells to remove peroxide from the culture medium, at a rapid rate, following the H2O2-pulse. Hydrogen Peroxide catalase Oryctolagus cuniculus