Title : Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS.

Pub. Date : 2013 Jun 11

PMID : 23716697






2 Functional Relationships(s)
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1 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. NAD C-terminal binding protein 1 Homo sapiens
2 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. NAD C-terminal binding protein 1 Homo sapiens