Title : Thermostabilisation of the serotonin transporter in a cocaine-bound conformation.

Pub. Date : 2013 Jun 26

PMID : 23706649






1 Functional Relationships(s)
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1 Inhibitor binding assays showed that both of the thermostabilised SERT mutants bound [(125)I]RTI55 (beta-CIT) with affinity similar to that of the wild-type transporter, although cocaine bound with increased affinity (17- to 56-fold) whilst ibogaine, imipramine and paroxetine all bound with lower affinity (up to 90-fold). Ibogaine solute carrier family 6 member 4 Homo sapiens