Pub. Date : 2013
PMID : 23704996
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 2 | Calcium- and phorbol ester-triggered acrosomal exocytosis in permeabilized sperm was abrogated by different anti-MARCKS antibodies raised against two different domains, indicating that the protein participates in acrosomal exocytosis. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 3 | We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 4 | We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 5 | In non-permeabilized sperm, a permeable peptide of MARCKS ED also inhibited acrosomal exocytosis when stimulated by a natural agonist such as progesterone, and pharmacological inducers such as calcium ionophore and phorbol ester. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 6 | The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 7 | The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 8 | The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 9 | The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. | Calcium | myristoylated alanine rich protein kinase C substrate | Homo sapiens |