Title : Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

Pub. Date : 2013 Aug

PMID : 23704229






8 Functional Relationships(s)
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1 Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
2 Deletion of the rate-limiting GSH synthesis gene, glutamate-cysteine ligase modifier subunit (Gclm), leads to significantly lower GSH concentrations in all tissues including brain. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
3 Deletion of the rate-limiting GSH synthesis gene, glutamate-cysteine ligase modifier subunit (Gclm), leads to significantly lower GSH concentrations in all tissues including brain. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
4 Deletion of the rate-limiting GSH synthesis gene, glutamate-cysteine ligase modifier subunit (Gclm), leads to significantly lower GSH concentrations in all tissues including brain. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
5 Deletion of the rate-limiting GSH synthesis gene, glutamate-cysteine ligase modifier subunit (Gclm), leads to significantly lower GSH concentrations in all tissues including brain. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
6 Gclm null (Gclm (-/-)) mice provide a model of prolonged GSH depletion to explore the relationship between GSH, complex I inhibition, and dopamine loss in vivo. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
7 Gclm null (Gclm (-/-)) mice provide a model of prolonged GSH depletion to explore the relationship between GSH, complex I inhibition, and dopamine loss in vivo. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus
8 The results suggest that chronic deficiency of GSH in Gclm (-/-) mice was not sufficient to result in complex I inhibition or dopamine depletion perhaps due to homeostatic mechanisms but required an additional oxidative stress insult as shown with paraquat exposure. Glutathione glutamate-cysteine ligase, modifier subunit Mus musculus