Protein Name glutamate-cysteine ligase, modifier subunit
Organism Mus musculus
Gene ID 14630
Gene Symbol

Gclm

UniProt O09172 (GSH0_MOUSE), Q4FJZ6 (Q4FJZ6_MOUSE)
Relationships Total Number of functionally related compound(s) : 100
Total Number of Articles : 114
Description

glutamate-cysteine ligase, modifier subunit

Gene Summary

Enables glutamate-cysteine ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine ligase activity. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • glutamate--cysteine ligase regulatory subunit
  • GCS light chain
  • gamma-ECS regulatory subunit
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Properties