Pub. Date : 2014 Feb
PMID : 23697845
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib inhibits proteasomal degradation of IkappaBalpha and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 2 | Therefore, a panel of ABC cell lines was used to examine the effect of bortezomib, a proteasome inhibitor which blocks degradation of IkappaBalpha and consequently inhibits NFkappaB activity. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 3 | Furthermore, treatment of ABC cell lines with bortezomib for 48 h also down-regulated the expression of NFkappaB-regulated gene products, such as IkappaBalpha, Bcl-2, Bcl-Xl, XIAP and survivin, leading to apoptosis via the mitochondrial apoptotic pathway. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |