Title : Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines.

Pub. Date : 2013 Jul 1

PMID : 23695170






1 Functional Relationships(s)
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1 The inhibition of EGFR phosphorylation and of downstream signaling by adding gefitinib to metformin treatment abrogated this phenomenon and induced a strong apoptotic effect in vitro and in vivo. Metformin epidermal growth factor receptor Homo sapiens