Title : Peroxisome proliferator-activated receptor (PPAR) ╬│ and PPAR╬▒ agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?

Pub. Date : 2013

PMID : 23675519






1 Functional Relationships(s)
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1 Our results suggest that both a PPARgamma agonist (ciglitazone) and a PPARalpha agonist (WY 14.643) are able to protect neurons by modulating mitochondrial fusion and fission, leading to a better response of neurons to oxidative stress, suggesting that a PPAR based therapy could acts simultaneously in different cellular components. ciglitazone peroxisome proliferator activated receptor gamma Mus musculus