Title : Severe tremor after cotrimoxazole-induced elevation of venlafaxine serum concentrations in a patient with major depressive disorder.

Pub. Date : 2013 Jun

PMID : 23666577






1 Functional Relationships(s)
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1 The observed overall pharmacokinetic effect was most probably the result of decreased N-demethylation of venlafaxine by (1) reduced expression of CYP2C19 due to a genetic deficit and (2) inhibition of CYP2C9 by cotrimoxazole. Venlafaxine Hydrochloride cytochrome P450 family 2 subfamily C member 9 Homo sapiens