Title : Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction.

Pub. Date : 2013 Jul 4

PMID : 23660334






1 Functional Relationships(s)
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1 Sanguinarine generated ROS, which was followed by a decrease in the mitochondrial membrane potential (MMP), the activation of caspase-9 and -3, and the down-regulation of anti-apoptotic proteins, such as Bcl2, XIAP and cIAP-1. Reactive Oxygen Species caspase 9 Homo sapiens