Title : Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.

Pub. Date : 2013 Jun 13

PMID : 23656327






1 Functional Relationships(s)
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1 Synthetic modifications of the pyrimido[5,4-b]indole scaffold at the carboxamide, N-3, and N-5 positions revealed differential TLR4 dependent production of NFkappaB and type I interferon associated cytokines, IL-6 and interferon gamma-induced protein 10 (IP-10) respectively. 5H-pyrimido[5,4-b]indole interleukin 6 Homo sapiens