Pub. Date : 2013 Jul 1
PMID : 23651427
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug for diabetes and other obesity-related syndromes. | Metformin | yrdC domain containing (E.coli) | Mus musculus |
| 2 | By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). | Metformin | yrdC domain containing (E.coli) | Mus musculus |
| 3 | By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). | Metformin | yrdC domain containing (E.coli) | Mus musculus |
| 4 | In addition, we observed that the expression of IRIP was approximately half (P < 0.01) in ob/ob mice when compared to their lean littermates, with significant increases in hepatic Oct1 protein expression and metformin accumulation. | Metformin | yrdC domain containing (E.coli) | Mus musculus |