Title : Epidermal growth factor receptor transactivation by intracellular prostaglandin E2-activated prostaglandin E2 receptors. Role in retinoic acid receptor-β up-regulation.

Pub. Date : 2013 Sep

PMID : 23644172






1 Functional Relationships(s)
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1 Thus, EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha leading to increased production of VEGF-A and it may be a target for the therapeutic modulation of HIF-1alpha/VEGF-A. Dinoprostone retinoic acid receptor beta Homo sapiens