Pub. Date : 2013 Jun
PMID : 23640722
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | During a recent fragment screen, 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline (VUF10166) was identified as a ligand that displays an 83-fold difference in [(3)H]granisetron binding affinity between 5-HT3A and 5-HT3AB receptors. | 2-chloro-(4-methylpiperazine-1-yl)quinoxaline | 5-hydroxytryptamine receptor 3A | Homo sapiens |
| 2 | During a recent fragment screen, 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline (VUF10166) was identified as a ligand that displays an 83-fold difference in [(3)H]granisetron binding affinity between 5-HT3A and 5-HT3AB receptors. | 2-chloro-(4-methylpiperazine-1-yl)quinoxaline | 5-hydroxytryptamine receptor 3A | Homo sapiens |
| 3 | Fragment hit exploration, initiated from VUF10166 and 3-(4-methylpiperazin-1-yl)quinoxalin-2-ol, resulted in a series of compounds with higher affinity at either 5-HT3A or 5-HT3AB receptors. | 2-chloro-(4-methylpiperazine-1-yl)quinoxaline | 5-hydroxytryptamine receptor 3A | Homo sapiens |