Title : A view on EGFR-targeted therapies from the oncogene-addiction perspective.

Pub. Date : 2013

PMID : 23637683






1 Functional Relationships(s)
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1 In this regard we set forth several hypotheses; namely, that requirement of higher glucose uptake by hypoxic tumor cells may reinforce EGFR addiction; and that chronic use of EGFR-targeted antibodies in EGFR-addicted tumors would induce stable disease by reversing the malignant phenotype of cancer stem cells and also by sustaining an anti-tumor T cell response. Glucose epidermal growth factor receptor Homo sapiens