Pub. Date : 2013 Jul 1
PMID : 23624625
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | ANG II-mediated intraneuronal signaling has been shown to be predicated by an increase in mitochondrial superoxide (O2 -), yet the source of this reactive oxygen species (ROS) production remains unclear. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | ANG II-mediated intraneuronal signaling has been shown to be predicated by an increase in mitochondrial superoxide (O2 -), yet the source of this reactive oxygen species (ROS) production remains unclear. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 4 | Additionally, adenoviral-encoded small interfering RNA for Nox4 (AdsiNox4) caused a robust knockdown in Nox4 mRNA and protein levels, which led to the attenuation of ANG II-induced mitochondrial O2 - production. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 5 | Collectively, these data suggest that Nox4 is a source of O2 - in neuron mitochondria that contributes to ANG II intraneuronal signaling. | Superoxides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |