Title : Nitric oxide enhances increase in cytosolic Ca(2+) and promotes nicotine-triggered MAPK pathway in PC12 cells.

Pub. Date : 2013 Nov 1

PMID : 23624270






2 Functional Relationships(s)
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1 Treatment with nicotine stimulated ERK1/2 and p38 MAPK phosphorylation in the PC12 cells expressing nNOS (NPC12 cells) as compared with that in control PC12 cells. Nicotine mitogen activated protein kinase 3 Rattus norvegicus
2 These data suggest that NO promotes nicotine-triggered Ca(2+) transient in PC12 cells to activate possibly CaMKII, leading to sequential phosphorylation of p38 MAPK and ERK1/2. Nicotine mitogen activated protein kinase 3 Rattus norvegicus