Title : Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.

Pub. Date : 2013 Jun 1

PMID : 23623490






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Among the three Pim isoforms, Pim-2 is particularly important in multiple myeloma, yet is the most difficult to inhibit due to its high affinity for ATP. Adenosine Triphosphate Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens