Title : Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.

Pub. Date : 2013 Jun 7

PMID : 23620596






2 Functional Relationships(s)
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1 Significantly, the CYP17A1/b5 interaction is stronger when the hydroxylase substrate pregnenolone is present in the CYP17A1 active site than when the lyase substrate 17alpha-hydroxypregnenolone is in the active site. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Significantly, the CYP17A1/b5 interaction is stronger when the hydroxylase substrate pregnenolone is present in the CYP17A1 active site than when the lyase substrate 17alpha-hydroxypregnenolone is in the active site. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens