Pub. Date : 2013 Feb
PMID : 23617068
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In silico exploration of phenytoin binding site in two catalytic states of human P-glycoprotein models. | Phenytoin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Earlier studies have identified drug efflux due to the over-expression of P-gp as one of the causes for the resistance of phenytoin, an anti-epileptic drug (AED). | Phenytoin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | While no clear evidence exists on the specific characteristics of phenytoin association with the human P-gp, this study employed structure-based computational approaches to identify its binding site and the underlying interactions. | Phenytoin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Further, an in silico proof-of-concept for phenytoin interactions and its decreased binding affinity with the closed-state of human P-gp model was provided in comparison with other AEDs. | Phenytoin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | This is the first report to provide insights into the phenytoin binding site and possibly better explain its efflux by P-gp. | Phenytoin | ATP binding cassette subfamily B member 1 | Homo sapiens |