PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23615401-9 2013 Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products. Tetradecanoylphorbol Acetate 13-16 AKT serine/threonine kinase 1 Homo sapiens 77-80 23615401-10 2013 In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation. Tetradecanoylphorbol Acetate 54-57 AKT serine/threonine kinase 1 Homo sapiens 211-214